RQ-00203078 is a drug which acts as a potent and selective blocker of the TRPM8 ion channel, which is the main receptor responsible for the sensation of cold. It was developed as a potential analgesic, and blocks the development of hyperalgesia following exposure to cold temperatures or chronic morphine administration.
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{"type":"standard","title":"Puerto Rican Volunteers Corps","displaytitle":"Puerto Rican Volunteers Corps","namespace":{"id":0,"text":""},"wikibase_item":"Q7258611","titles":{"canonical":"Puerto_Rican_Volunteers_Corps","normalized":"Puerto Rican Volunteers Corps","display":"Puerto Rican Volunteers Corps"},"pageid":7712939,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/1/16/Plana_Major_Primer_Batallo_de_voluntaris_de_Puerto_Rico_1897.JPG/330px-Plana_Major_Primer_Batallo_de_voluntaris_de_Puerto_Rico_1897.JPG","width":320,"height":197},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/1/16/Plana_Major_Primer_Batallo_de_voluntaris_de_Puerto_Rico_1897.JPG","width":526,"height":324},"lang":"en","dir":"ltr","revision":"1233827004","tid":"f5684c46-3f30-11ef-85ec-6e4bd9099875","timestamp":"2024-07-11T02:54:58Z","description":"Private citizens defense militia","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Puerto_Rican_Volunteers_Corps","revisions":"https://en.wikipedia.org/wiki/Puerto_Rican_Volunteers_Corps?action=history","edit":"https://en.wikipedia.org/wiki/Puerto_Rican_Volunteers_Corps?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Puerto_Rican_Volunteers_Corps"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Puerto_Rican_Volunteers_Corps","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Puerto_Rican_Volunteers_Corps","edit":"https://en.m.wikipedia.org/wiki/Puerto_Rican_Volunteers_Corps?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Puerto_Rican_Volunteers_Corps"}},"extract":"The Puerto Rican Volunteers Corps was a militia composed of private citizens, principally instituted for the defense of Puerto Rico from foreign invasion and local uprisings. Following the example of Cuba, this militia was first established in December 1864 in order to fill the void left by the units of the local garrison sent to the war in Santo Domingo (1863–1865). After a few first years of barely any activity, several Volunteer units were created across the island as a result of the Grito de Lares, the incipient first outcry for independence in Puerto Rico of September 23, 1868. In principle, the volunteers were characterized by their unwavering loyalty to the Spanish Crown, and as such were closely associated to the Partido Incondicionalmente Español. This party was opened to all Spaniards, both Creoles and peninsulares, but the latter played a prominent role providing many of its leaders and ranks. Many in the island's elite joined the Volunteers as a symbol of social status and loyalty to Spain.","extract_html":"
The Puerto Rican Volunteers Corps was a militia composed of private citizens, principally instituted for the defense of Puerto Rico from foreign invasion and local uprisings. Following the example of Cuba, this militia was first established in December 1864 in order to fill the void left by the units of the local garrison sent to the war in Santo Domingo (1863–1865). After a few first years of barely any activity, several Volunteer units were created across the island as a result of the Grito de Lares, the incipient first outcry for independence in Puerto Rico of September 23, 1868. In principle, the volunteers were characterized by their unwavering loyalty to the Spanish Crown, and as such were closely associated to the Partido Incondicionalmente Español. This party was opened to all Spaniards, both Creoles and peninsulares, but the latter played a prominent role providing many of its leaders and ranks. Many in the island's elite joined the Volunteers as a symbol of social status and loyalty to Spain.
"}